Clomiphene is a weak selective estrogen receptor modulator (SERM) antagonist at the level of the hypothalamus. When attached to the receptors, it down-regulates the negative effects of estradiol, which means clomiphene increases GnRH production. The down-stream effect is that the pituitary gland increases production of FSH and LH, thus stimulating sperm and testosterone production.
Enclomiphine is one of two isomers found in Clomid. It is thought to be responsible for the beneficial effects of Clomid on FSH and LH. The other isomer in Clomid (zuclomiphene) is thought to cause many of the side effects.
These medications we offer to treat low testosterone in men are considered off-label. This means the FDA has not specifically approved the medication for treating low testosterone. However, healthcare professionals have the discretion to prescribe medications off-label if they believe it is an appropriate course of treatment for a particular patient.