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Enclomiphene vs. Clomiphene: Understanding The Difference

By Josh Whalen
October 7, 2023

In the world of men's health, testosterone plays a pivotal role. It's responsible for muscle growth, bone density, libido, and various other physiological functions. As men age, testosterone levels can decline, leading to a myriad of health issues. This has led to the search for effective testosterone boosters. Among the contenders, two drugs stand out: Enclomiphene and Clomiphene. While both are used to increase testosterone levels, their mechanisms of action differ significantly. Let’s look into the "Enclomiphene vs. Clomiphene" debate to shed light on their differences.

What are Enclomiphene and Clomiphene?

Before diving into their differences, it's essential to understand what these drugs are.

Enclomiphene: A non-steroidal estrogen receptor antagonist, Enclomiphene is primarily used for treating men with secondary hypogonadism. It's the trans-isomer of Clomiphene citrate and has been shown to increase testosterone levels without affecting the pituitary or sperm production.

Clomiphene: Often prescribed for female infertility, Clomiphene citrate is a mixture of two geometric isomers: zuclomiphene and enclomiphene. In men, it's used off-label to treat low testosterone levels. It works by blocking estrogen receptors in the brain, leading to an increase in natural testosterone production.

Mechanism of Action: How Do They Work?

The primary distinction between Enclomiphene and Clomiphene lies in their mechanisms of action.


Estrogen Receptor Antagonist: Enclomiphene acts as an antagonist at estrogen receptors, particularly in the hypothalamus. By doing so, it interrupts the negative feedback of estrogen on the hypothalamus.

LH and FSH Increase: This interruption leads to an increase in the secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the pituitary gland. These hormones subsequently stimulate the testes to produce more testosterone.


Mixed Isomer Action: Clomiphene contains both enclomiphene and zuclomiphene isomers. While enclomiphene increases testosterone, zuclomiphene has estrogenic activity, which can counteract some of the testosterone-boosting effects.

Prolonged Action: Due to the presence of zuclomiphene, which has a longer half-life, the effects of Clomiphene can be more prolonged and variable in men.

Pros and Cons of Enclomiphene vs. Clomiphene

Both drugs have their advantages and limitations when it comes to boosting testosterone.


Pros: More consistent testosterone increase, no impact on sperm production, and fewer side effects due to the absence of zuclomiphene.

Cons: Still under research for its long-term effects and safety profile.


Pros: Well-researched, proven efficacy in increasing testosterone levels, and has been used for years in treating male hypogonadism.

Cons: The presence of zuclomiphene can lead to variable results and potential estrogenic side effects.

Testosterone Therapy at Blokes

The "Enclomiphene vs. Clomiphene" debate doesn't have a one-size-fits-all answer. The choice between the two depends on individual needs, the specific health scenario, and the guidance of a healthcare professional. While Enclomiphene offers a more targeted approach with potentially fewer side effects, Clomiphene has a longer track record and established efficacy. Consult our team of experts at Blokes for help determining the best option for boosting testosterone levels safely and effectively.

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